منابع مشابه
Genetics of cardiovascular disease.
Fifty years ago, cardiovascular genetics simply did not exist. Genetics was a nascent field of basic research, with little apparent relevance to cardiovascular science or any other medical subspecialty. Today, cardiovascular genetics is a discipline that fully integrates high-technology laboratory investigation and clinical medicine. From this hybrid have emerged discoveries that have precisely...
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Cardiovascular disease encompasses a range of conditions extending from myocardial infarction to congenital heart disease, most of which are heritable. Enormous effort has been invested in understanding the genes and specific DNA sequence variants that are responsible for this heritability. Here, we review the lessons learned for monogenic and common, complex forms of cardiovascular disease. We...
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Alzheimer's disease is a progressive neurological disorder that causes the brain to shrink (atrophy) and brain cells die. Alzheimer's disease is the most common cause of dementia and causes a decrease in thinking skills and social behaviors. Alzheimer's disease is more common in people over 65 years old. The risk of developing Alzheimer's disease and other types of dementia increases with age,...
متن کاملGenetics of hyperhomocysteinaemia in cardiovascular disease.
Homocysteine, a sulphur amino acid, is a branch-point intermediate of methionine metabolism. It can be degraded in the transsulphuration pathway to cystathionine, or remethylated to methionine via the remethylation pathway. In both pathways, major genetic defects that cause enzyme deficiencies are associated with very high plasma homocysteine concentrations and excretion of homocystine into the...
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Can we today apply genetics to individual patients and tailor therapy based on genetic profile to improve pharmacodynamics and kinetics [1]? This is an interesting question especially for the treatment of hypertension as substantial heterogeneity in efficacy exists in response to drug therapy. Individualised medicine may guide physicians in their choice instead of the old-fashioned trial-and-er...
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ژورنال
عنوان ژورنال: Heart Views
سال: 2020
ISSN: 1995-705X
DOI: 10.4103/heartviews.heartviews_140_19